Acute pancreatitis is an acute inflammatory process of the pancreas, with variable involvement of other regional tissues or remote organ systems. Acute pancreatitis may have two different clinical forms: mild and severe. Mild acute pancreatitis is associated with minimal organ dysfunction and an uneventful recovery. Severe acute pancreatitis is associated with organ failure and/or local complication, such as necrosis, pseudocysts or abscesses and with mortality of 10 - 20 %. Acute ancreatitis has often a rapid onset and is accompanied by upper abdominal pain, nausea and vomiting, tachycardia, hypotension and elevated pancreatic enzymes in blood and/or urine. Early prognostic evaluation of acute pancreatitis is basic for management of acute pancreatitis because treatment of severe form of acute pancreatitis is more aggressive than that of a mild form. Therapy must be in hospital with monitoring of vital functions, replacement of fluids and electrolyts. Prophylactic antibiotics are recommended in severe forms. Treatment of complications is symptomatic.