Jarmila Kabátová, Rastislav Husťak
The revised ESPGHAN guidelines (2012) for diagnosis of coeliac disease (CD) in children and adolescents identified specific
requirements for omitting intestinal biopsies in symptomatic patients who meet specific criteria:
a) be positive to anti TG2 level≥10 times the upper limit of normal for the screening laboratory, b) are known to have human
leukocyte antigen (HLA) typing consistent with CD and c) who have positive test results for antiendomysial antibody
(EMA). Symptoms associated with celiac disease are therefore the first and essential conditions for this approach.
The aim of this analysis of 258 children and adolescents with coeliac disease was to apply the revised ESPGHAN guidelines
retrospectively in this cohort of patients and to evaluate the possibility to omit enterobiopsies in symptomatic individuals.
In detail, there were analysed all symptoms associated with the incidence of celiac disease in both symptomatic
and asymptomatic patients in the context of corresponding histological findings obtained from duodenal sampling.