Background: Mucosal pseudolipomatosis of the colon is a very rare histopathologic entity. Its prevalence does not exceed 1% of all biopsy samples obtained by colonoscopy.
Case report: The author describes a 61-year old man, who underwent a colonoscopy and was found to have whitish mucosal plaques in the transverse colon. Microscopically, the lamina propria was occupied by optically empty spaces resembling adipocytes. Histochemical staining did not demonstrate an accumulation of glycogen or mucin within these empty spaces. Further, immunohistochemical staining for S-100 protein and CD34 were also negative, which excluded their adipocytic or vascular origin. The diagnosis of mucosal pseudolipomatosis was done.
Conslusion: Mucosal colonic pseudolipomatosis is a prognostically benign condition, that does not require a treatment and has a tendency of spontaneous remission. Although it shows characteristical microscopic picture, a disclosure of the correct diagnosis may not always be easy, because a pathologist usually does not consider it. The purpose of the current paper was to point out this interesting histopathological entity that may sometimes be encountered in gastroenterological practice.