Venous thromboembolism, pre-eclampsia, and pregnancy loss are still important complications or duration disorders of pregnancy. Heritable and acquired prothrombotic factors lead to an increased risk of thromboembolism. They can impair the outcome of pregnancy and play a role in the pathogenesis of spontaneous abortions. In recent years thrombophilia in these conditions has gained much attention. Available data suggest associations for pregnancy loss and antiphospholipid antibodies, antithrombin deficiency, hyperhomocysteinemia, factor V Leiden, prothrombin G20210A variation, and protein S deficiency. The contribution of thrombophilia to the onset of pre-eclampsia is less well established. The increased risk of thromboembolism is observed in the use of oral contraceptives and oral hormone replacement therapy. Screening for thrombophilia in women with pregnancy loss and in women candidate to the pill is still a matter of debate.