Božena Pekárková, Boris Pekárek, Jarmila Kabátová
Celiac sprue is a lifelong systemic disease, characterized by permanent gluten intolerance on an autoimmune basis, resulting in damage of the small intestine mucosa and alteration of the immune system. This disease occurs with genetically predisposed individuals who consume prolamines found in wheat, rye, barley, and oats. It can be manifested through intestinal or extraintestinal symptoms, and is often oligosymptomatic. The only known treatment and prevention of complications is a lifelong gluten-free diet.