Téma:  Case Studies

Wegener´s granulomatosis – a rare cause of renal failure in an elder female patient

Katarína Bobocká, Jozef Kalužay, Patrik Podaný, Darmar Eisnerová, Peter Ponťuch

Wegener´s granulomatosis is a systematic disease - a granulomatosis necrotizing vasculitis that has a predilection impairment of medium and small-sized vessels of airways and kidneys. We demonstrate clinical course of this disease in a 76-year-old polymorbid woman. As a part of the search for the causes of progressive renal insufficiency the presence for cANCA antibodies was tested. The positive results of the tests supported our suspicion for systemic vasculitis. Initiation of immunosuppressive treatment (prednisone and cyclophosphamide) was a key step which was followed by rapid improvement of clinical status, bronchopulmonary symptoms subsided, but patient remained hemodialysis-dependent. We highlight the need for ANCA testing as a part of differential diagnostic process and life-saving treatment with cyclophosphamid and prednisone even in polymorbid immunocompromised patients is demonstrated too.

Ročník 2009  Témy časopisu Internal medicine 9 / 2009

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REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
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MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
doc. MUDr. Ján Podoba, CSc.
prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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