Celiac disease is a known systemic disease with a number of hematologic manifestations. Patients with celiac disease can present many hematological complications even before establishing the diagnosis of celiac disease. Secondary anemia due to iron malabsorption, folic acid and vitamin B12 is a common complication of celiac disease and many patients suffer from anemia during diagnosis. Celiac disease id associated with thrombocytosis, thrombocytopenia, leukoenia, venous thromboembolism, hyposlenism and IgA deficiency. The patients with celiac disease have high risk of lymphoma development, mostly of T-cells. The highest risk is for EATCL and B-cells lymphoma of bowel, but extraintestinal lymphomas can also develop. EATCL is an aggressive conditions with bad prognosis but strict adherence to glutein-free diet should prevent the development.