Marta Petríková, Miroslav Kubeš, Peter Takáč, Milan Kozánek
In spite of advance in the understanding of the molecular and cellular processes in healing, the vast cutaneous wounds or chronic wounds still represent an acute problem worldwide. The healing of acute or chronic dermal wounds results in accelerated wound closure with increased epithelialization, granulation tissue formation and angiogenesis. Although MSC differentiate in the wound, the therapeutic effect is more likely due to release of soluble factors which regulate local cellular responses to cutaneous injury. This article provides the review of the growing evidence demonstrating the key role of stem cells in wounds healing and the promising use of the adult mesenchymal stem cells in chronic wound healing or impaired wound healing.
Key word: wound healing, mesenchymal stem cells, chronic wounds