Chronic venous disease (CDV) became the most frequent disease in developed countries. Its treatment must be complex and life-long. A thorough ultrasonographic examination of venous system of lower extremities is crucial for disease evaluation and namely for the choice of possible active sclerosing or surgical treatment. In the initial stages, conservative therapy and sclerotherapy of spiderveins and phlebectasia is indicated. In the stage of varicose veins surgical or endovenous treatment is needed as a rule. This is best if indicated prior to the occurrence of other skin changes or other complications of CHVD. In the most serious stage of the disease – the presence of ulcus cruris, angiology examination is decisive in terms of further treatment. It is necessary to rule out the share of artery disease as a cause of trophic skin changes and in venous ulcus to intensify the conservative therapy and optimise local therapy. Prevention against recurrence of venous ulcus is to eliminate the main source of venous reflux by surgical or endovenous treatment or by sclerotherapy.