Zora Krivošíková, Patrícia Kramárová, Martin Gajdoš
Obesity and osteoporosis are complex chronic diseases with multifactorial aetiology and some common features. They both have rising prevalence and contribute to rising mortality and morbidity, too. Although obesity is a serious risk factor in many chronic diseases, in the terms of osteoporosis, the effect of it on the bone was considered to be more beneficial. The higher mechanical loading of body weight on bone as well as the higher peripheral production of estrogenes from androgens through the aromatase action was the usual explanation for this effect. On the contrary, the latest findings about the regulation of adipo and osteoblastogenesis in bone marrow and also about endocrine effects of fat tissue on bone metabolism point out more to detrimental effects of fat tissue on bones. We focused on this topic in our work.