Better understanding of radiotherapy-induced late cardiovascular effects (manifesting more than 1 year after completion of radiation therapy) represents an important step in improvement of management of cancer survivors. Radiotherapy-induced cardiovascular damage may range from mild abnormalities to life-threatening outcomes. The most studies indicate the late cardiovascular complications after radiotherapy in survivors of Hodgkin’s lymphoma, breast cancer and seminoma. Heart disease may be induced or exacerbate by mediastinal, head and neck, spinal, abdominal and axillary radiotherapy. Widely accepted evidence-based guidelines for follow up of cancer survivors after radiotherapy remain to be determined.