Vincent Nagy, Ivica Lazúrová, Ingrid Dravecká, Jagienka Jautová, Janette Baloghová, Ladislav Valanský, Ľubomír Lachváč
Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy in women of reproductive age. Given the complexity of related symptoms of women with PCOS and signs of autosomal inheritance it is presumed to have been the male equivalent of PCOS. Objective of the study: The aim was to determine the existence of a male equivalent of polycystic ovary syndrome (PCOS) in younger men with hormonal imbalance and androgenic alopecia. Clinical Material and methods: In 2010-2011 we examined 22 patients with a mean age of 31.7 ± 7.9 years. For all we have done dermatological examination to exclude other causes of alopecia (16/22 in the skin biopsy), urology (sexology) and internal examination. There were examined plasma glucose and insulin levels, with the calculation of insulin resistance index HOMA (Homeostasis Model Assessment: glucose x insulin / 22.5), lipids: total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, hormone profile: total and free testosterone, free androgen index (FAI), sex hormone binding globulin (SHBG), follicle stimulating hormone (FSH), luteinizing hormone (LH) and anthropometric parameters: weight, height, waist circumference and body mass index (BMI: weight/height 2). Results: One patient (4.5 %) was confirmed by new onset type 2 diabetes and 3 patients (13.6 %) were confirmed by insulin resistance. Metabolic dyslipidaemia (hypertriglyceridaemia, low HDL cholesterol or elevated LDL cholesterol) occurred in 8 patients (36 %). Increased levels of testosterone were found in only 1 patient (4.5 %), increased FAI in 4 patients (18.18 %), and decreased SHBG in 2 subjects (9 %). Overweight and obesity have been confirmed in 40 % (9 patients). Conclusion: The existence of male equivalent of PCOS has not been proven yet, but there were confirmed the features of the metabolic syndrome, marginally higher fasting blood glucose, elevated LDL cholesterol and overweight. We found significant changes in hormonal parameters. For financial reasons, we examined only a limited number of patients without a control group, the study is continued.