Based on increasing number of HIV infected people not only in the world, but also in the Slovak Republic, early and properly chosen combination antiretroviral therapy is important. The aim of this treatment is to achieve deep viral suppression of HIV replication, prolonged life of a patient and better quality of life. At indication of the therapy several complicated therapeutic regimens are used. Regarding the adherence of the patient the simplified regimens are preferred. The highest level of them is STR / single tablet regimen/ containing co-formulation of drugs for the daily dose in a single tablet. Actually in Slovakia there are two preparations available – RPV/TDF/FTC and EVG/COBI/TDF/FTC. All regimens has to be chosen according to the clinical stage, age, comorbidity and partner.