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Časopis Internal medicine – Článok Pharmacogenetic study of gene variants encoding metformin transporters in patients with diabetes mellitus type 2

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: Original Works

Pharmacogenetic study of gene variants encoding metformin transporters in patients with diabetes mellitus type 2

Mária Štolfová, Lucia Klimčáková, Eva Babjaková, Igor Gaľa, Zbynek Schroner, Ivan Tkáč, Martin Javorský

In clinical practice we observe important interindividual variability in glucose-lowering effect of metformin in type 2 diabetic patients with probable contribution of genetic factors. The aim of this study was to investigate the possible relationship of variants of genes encoding metformin transporter proteins including organic cation transporter 1 (OCT1) (gene SLC22A1), multidrug and toxin extrusion 1 (MATE1) (SLC47A1) and MATE2 (SLC47A2) with the response to metformin treatment. Effect of 6-month monotherapy with metformin were followed in a group of 148 drug-naive patients with newly diagnosed type 2 diabetes treated with metformin from the time of diagnosis of diabetes for at least 6 months. Mean decrease in glycated haemoglobin (HbA1c) was 0.66 ± 0.08 %. Genotypes for SLC22A1 rs683369 C > G, SLC47A1 rs8065082 C > T and SLC47A2 rs12943590 G > A were determined with PCR followed by melting curve analysis. Among the gene variations we observed in the multivariate linear model a significantly greater decrease in HbA1c for the minor T-allele of SLC47A1 rs8065082 (β = 0.19, 95 % CI 0.02 to 0.35, p = 0.032). In the multivariate logistic model T-allele was also significantly associated with a higher chance of achieving therapeutic goal (HbA1c < 7 %): odds ratio (OR) 1.87 (95 % CI 1.04 to 3.37, p = 0.038). Our results indicate that each T-allele in SLC47A1 rs8065082 genotype is associated with incremental, by 0.19 % higher reduction of glycated haemoglobin during 6-month metformin treatment. In the future these results could contribute to personalization of type 2 diabetes treatment.

pharmacogenetics, gene variant, metformin
Interná med. 2014; 14 (6): 264-267

Ročník 2014  Témy časopisu Internal medicine 6 / 2014

Overview works

Jana Hoozová, Štefan Krajčík
Soňa Kiňová
Katarína Šimeková

Original Works

Mária Štolfová, Lucia Klimčáková, Eva Babjaková, Igor Gaľa, Zbynek Schroner, Ivan Tkáč, Martin Javorský

Clinical pharmacology

Zbynek Schroner, Vladimír Uličiansky

Case Studies

Naďa Hučková, Marián Kozlovský, Vasiľ Hricák
Nie sú dostupné žiadne voľne dostupné články
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REPRESENTATIVE OF CHAIRMAN
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MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
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doc. MUDr. Oľga Jurkovičová, CSc.
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prof. MUDr. Peter Mitro, PhD.
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prof. MUDr. Juraj Payer, CSc., FRCP
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné