Summary: Nowadays cholestatic liver diseases occur considerably more frequently than in the past. Up to 1/3 of all laboratory
examinations are related to laboratory syndrome of cholestasis (with GMT increase). It is a consequence of increase
in obesity in the population, of metabolic syndrome and non-alcoholic steatosis (NAFLD) as well as of the contribution
of alcoholic liver disease. Recent years have brought also the definition of a new clinical unit IgG4-associated
cholangitis, better understanding of cholestatic diseases and even new diagnostic criteria for drug hepatotoxicity. The
European Association for Study of the Liver brought recommendation for the management of cholestatic liver diseases
and differential-diagnostic algorithm. The paper as a survey summarises particular cause of cholestatic in adults, its
definition and main characteristics.