Functional changes of anorectal area are narrowly related to anatomical findings. The major pathway for communication between brain and gut are vagal, splanchnic and sacral nerve tracks and the so called short neurons. This communication can explain some sensations like tenesmus, proctalgia fugax, diarrhea, constipation but also consequences of long-lasting spasm of sphincter of the anus with insufficient blood supply, fissures and ulcers. Therapy of benign organic changes of anorectal area (fissures, fistulas) depends on dietary habits adjustment, sphincter divulsion, botulotoxin injection or sphincterotomy. In case of hemoroidal nodes – apart of dietary changes, venotonics, heparoid, ketazon, the next modality would be sclerotherapy, cryosurgical procedures, and radioblation methods.