Kvetoslava Rimárová, Peter Makovický
Celiac disease is common disorder in children and also adults all over the world. This disease is connected with permanent intolerance of gluten which is a part of some cereals. In a clinical practice there are distinguished a number of disease forms whereas the typical form is found in small of cases and the others are supposed as an atypical. Recent studies show that this disorder is still under-diagnosed in the world. Symptoms of atypical disorders forms are often non-specific and they don’t bear witness to celiac disease eventually. With respect to this fact it was proposed many ways for the detection of atypical forms of celiac disease in population of children and adult individuals in former times, but the biopsic investigation of duodenum samples remains by the golden standard in existence. In the aimed diagnostic algorithm are prior to the biopsy less invasive methodologies. These are applied especially in the atypical forms and they are based on the quantification of circulating antibodies in the serum. Their application has many advantages, but practical experience had shown that their informative value are not always convincing. By our opinion the diagnostic samples should be collected on departments with immunohistochemic profile. Searching of risk groups with the atypical celiac disease is an interdisciplinary problem and therefore it needs cooperation of all branches of medicine.