Mária Zakuciová, Martin Janičko
As IBD appears in the fertile age, in many cases we encounter with problems of mutual influencing of IBD and fertility, course of gravidity, foetal development, labour and peurperium. It is known that there is a mutual relation between IBD, course of gravidity and foetal development. Besides that, humoral, hormonal and haemodynamic changes in the course of gravidity and puerperium influence the IBD. Fertility of patients with IBD is influenced minimally, psychosocial factors (fear of gravidity, inheritance of the disease, relationship problems, and inappropriate therapeutical recommendations) play more important role. In the case of conception in the period of remission, complications appear approximately as often as in healthy women, but during gravidity there is a higher risk of disease relapse. 1/3 of relapses appear in the first trimester, in the case of conception in the period of relapse the activity persists or is worsened in 2/3 of patients. Majority of medicaments for the treatment of the active disease seems to be safe. The active disease during pregnancy should be treated aggressively as the risk of untreated disease is higher than the risk of treatment. Relatively extensive population studies showed that mothers with IBD have higher risk of premature labour or lower birth weight, but these data were not correlated with the grade of disease activity.