Miroslav Šašinka, Katarína Furková, Ľudmila Podracká
The etiology of nephrotic syndrome has substantially changed and the number of prognostically serious forms, mainly focal and segmental glomerulosclerosis are on the increase. In dependence on the etiology the therapy has also undergone significant changes. The authors discuss modern forms of nephrotic syndrome therapy, its general principles (principles of way of living and physical activity, dietary measures and prevention of complications) and specific therapeutic procedures dependent on the type of nephropathy causing nephrotic syndrome - diuretic therapy, glucocorticoids, cytotoxic classic immunosuppressives (cyclophosphamide, chlorambucil) and new ones (cyclosporine A, mycophenolate mophetil). The authors stress the possibilities of positive affecting the progression also in patients resistant to the currently known therapy (plasmapheresis, lipid apheresis) with particular emphasis upon the treatment of evidence-based medicine.