Daniela Dudášová, Ivica Lazúrová
Insulin resistance with compensatory hyperinsulinemia can be a primary metabolic defect associating various features of metabolic syndrome. The increased levels of glucocorticoids contribute in many cases on impaired insulin sensitivity. Hyperinsulinemia and insulin resistance are frequent findings in patients with endogenous and exogenous hypercortisolism. Clinical syndrome of glucocorticoid excess is associated with glucose intolerance, obesity and hypertension. In addition, changes in cortisol levels within the physiological range may contribute to insulin resistance and its association with other cardiovaskular risk factors.