Ján Koreň, Daniela Kotulová
Septic diseases in the healthcare facility nowadays are caused by various microbial agents with property of nosocomial pathogens in the appropriate setting. These infections can have endogenous origin with secondary acquired drug resistance of physiological flora by antibiotic selection pressure. By repression of growth of sensitive bacteria patient is colonized with multiplication of resistant strains` population e. g.: methicillin-resistant coagulase-negative Staphylococcus strains (MRCoNS), methicillinresistant Staphylococcus aureus (MRSA), enterobacteria with production of extended spectrum β - lactamases (ESBL) and other. Exogenous nosocomial infections arise by transfer of microorganisms between hospitalized patients, staff and setting. The aim of our work was to characterized nosocomial pathogens like agents of septic states, to describe what diseases they often caused, acquired resistance to antibiotics and what is the most suitable antiinfectious agents for treatment.