Etela Janeková, Milan Kriška
Modern medicine extensively utilizes drugs of various origin, increasingly in combinations, as in a monotherapy therapeutical goals are not achieved. It is proved in recommended therapeutical guidelines for hypertension, chronic heart failure, DM, AIDS, peptic ulcer disease and other various diseases. Besides positive results of drug interactions a possible negative response might originate to treatment as an adverse effect. Contrary to well-developed health care, in domestic literature questions of drug interactions are rarely discussed. The problem is identification and prevention of clinically relevant interactions, which is discussed in our paper.