The pheochromocytoma is not a common condition. Mostly it is a benign tumour arising from the chromaffin cells of the adrenal medulla. In case the tumour arises from the extraadrenal chromaffin cells, we talk about a paraganglioma. The clinical manifestation is variable, ranging from asymptomatic forms to the disease with the classical triad of symptoms: the attacks of palpitations, headaches and profuse sweating. This triad is usually associated with hypertension - permanent or paroxysmal. The release of catecholamines is manifested by attacks of tachycardia paleness, sweating, anxiety, nausea, abdominal pain, polyuria and polydipsia. In addition to the patient history and physical examination, imaging techniques and the laboratory diagnosis of catecholamines overproduction take important part in the diagnostic process. This paper describes the case of a patient with many years lasting pheochromocytoma and with the process after the operation.