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Časopis Internal medicine – Článok Oxidative-and carbonyl-stress markers in haemodiafiltration patients

Internal medicine

Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné
Téma: 

Oxidative-and carbonyl-stress markers in haemodiafiltration patients

Miroslav Mydlík, Katarína Derzsiová, Katarína Javorská, Katarína Šebeková, Ivana Koborová, Radana Gurecká

End stage renal disease (ESRD) is characterized (among others) by enhanced microinflammation, oxidative- and carbonyl-
stress.The aim of the study was to investigate the effect of haemodiafiltration (HDF) on the variables associated
with the above mentioned conditions in patients (pts) with (DM) or without diabetes mellitus (nDM). In 7pts with DM
(age: 55 ± 14 yrs) and 14 nDM pts (age: 63 ± 12 yrs) except standard biochemical parameters, plasma advanced glycation
end-products (AGEs) by spectrofluorometric method, plasma Nε-carboxymetyllysine (CML) was determined by ELISA
kit MicroCoat, Bernried, Germany, advanced oxidation protein products (AOPPs), total antioxidant capacity (TAC),
fructosamine (FTA), and ferric reducing ability of plasma (FRAP) by photometric methods, tissue inhibitor of metalloproteinases-
1 (TIMP-1) and monocyte chemoattractant protein-1 (MCP-1) by ELISA methods were determined. DM and
nDM groups differed significantly in the pre-HDF AGEs/Alb (19.5 ± 3.3 resp. 23.0 ± 4.7 AU/g, p<0.05), CML/Alb (94.3 ±
30.1 resp. 118.8 ± 55.5 μg/g, p < 0.05) and TIMP-1 (144.5 ± 49 resp. 203 ± 87 ng/mL, p < 0.01); and in the post-HDF FRAP
(706 ± 233 resp. 466 ± 151 μmol/L, p<0.05) levels. In comparison with basal values post-HDF levels of AGEs/Alb, TAC
and FRAP were significantly lower in both groups, while those of FTA, TIMP-1 and MCP-1 did not differ significantly.
Our data suggest that in HDF treated ESRD patients presence of DM modulates some markers of oxidative-and carbonyl-
stress and those of microinflammation. In both subgroups HDF ameliorates only some of the investigated parameters.
The effects of HDF were more pronounced in the nDM patients. Paradoxical finding of lower pre-HDF levels of AGEs/
Alb-associated fluorescence of plasma and plasma CML/Alb, and TIMP-1 in the DM vs. nDM pts remains unclear, but
might reflect the adherence of the DM patients to the recommended diet.

chronic renal failure, patients with and without diabetes mellitus, haemodiafiltration, oxidative and carbonyl stress
Interná med.; 15 (7-8): 324-328

Ročník 2015  Témy časopisu Internal medicine 7 / 2015

Jozef Holomáň
Miroslav Mydlík, Katarína Derzsiová, Katarína Javorská, Katarína Šebeková, Ivana Koborová, Radana Gurecká
Anna Gvozdjáková, Jarmila Kucharská, Oľga Vančová, Oľga Uličná
Iveta Šimková, Anna Remková, Marcela Boháčeková, Tatiana Valkovičová, Monika Kaldarárová
Viera Kupčová
Ľubomír Skladaný, Svetlana Adamcová-Selčanová, Erika Čellárová
Mária Szántová
Michaela Fedelešová, Ľubomír Valko
Viliam Mojto
Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Ivica Lazúrová, CSc. FRCP

REPRESENTATIVE OF CHAIRMAN
prof. MUDr. Juraj Payer, CSc., FRCP

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Viera Fábryová, CSc.
MUDr. Viera Fedelešová, CSc.
prof. MUDr Martin Haluzík, CSc.
prof. MUDr. Štefan Hrušovský, CSc. Dr.SVS.
prof. MUDr. Rudolf Hyrdel, CSc.
doc. MUDr. Oľga Jurkovičová, CSc.
doc. MUDr. Zdenko Killinger, PhD.
doc. MUDr. Soňa Kiňová, PhD.
prof. MUDr. Peter Mitro, PhD.
doc. MUDr. Viliam Mojto, CSc., MHA
prof. MUDr. Karel Pacák, DrSc.
prof. MUDr. Juraj Payer, CSc., FRCP
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prof. MUDr. Igor Riečanský, DrSc.
doc. MUDr. Ján Staško, PhD.
doc. MUDr. Mária Szántová, PhD.
prof. MUDr. Ivan Tkáč, PhD.

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Examples of citations:
1. Shaheen NJ, Crosby NA, Bozymski EM, et al. Is there publication bias in the reporting cancer risk in Barrett ́ esophagus? Gastroenterology 2000; 119: 333-338.
2. Stenestrand U, Wallentin L. Swedish Register of Cardiac Intensive Care (RIKS-HIA): Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001; 285(4): 430-436.
3. LIPID Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998; 339: 1349-1357.
4. Jurkovičová O, Spitzerová H, Cagáň S. Komorové arytmie a náhla srdcová smrť pri akútnom infarkte myokardu. Bratisl Lek Listy 1997; 98: 379-389.
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b. Scandinavian origin
c. propionibacterium acnes
d. endothelial growth factor


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patient internists and general practitioners.


Send contributions in the e-mail to the address: stachova@amedi.sk
Period 11x per year (july - august double issue)
1335-8359
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Internal medicine
Internal medicine
Peer - Reviewed Postgraduate Medical Journal.
Period 11x per year (july - august double issue)
Predplatné