Diabetic nephropathy is the most common cause of end-stage kidney disease worldwide, and is associated with increased
morbidity and mortality in patients with both type 1 and type 2 diabetes. Increasing prevalence of diabetes
has made the need for new therapeutic targets to improve clinical management. In 2013 was established the DIABESITY
group of ERA – EDTA to regular educate and training of diabesity for both the medical community and patients.
Autophagy is an essential mechanism to maintain homeostasis of glomeruli and tubules. Impairment of autophagy
is implicated in the pathogenesis of diabetic nephropathy. To activate and restore the autophagic pathway can be
a therapeutic target against diabetic nephropathy. Glomerular hyperfiltration is risk factor for decreasing the kidney
function. The salt restriction in food and kidney hemodynamic play important role in treatment of diabetic nephropathy.
We also highlight recent factors of pathogenesis and threatment of diabetic nephropathy.