Marián Švajdler ml., Peter Bohuš
Clinical and pathological diagnosis of autoimmune gastritis (AIG) in older patients with pernicious anemia is usually simple. Younger patients with atypical symptoms such as obscure sideropenic anemia can be a diagnostic challenge. The most important risk for the patients with AIG is adenocarcinoma. In addition, in a small percentage of patients, hypergastrinemia and subsequent ECL cell hyperplasia may lead to developement of well differentiated neuroendocrine tumour – carcinoid. These tumours are almost invariably benign and – in comparison with the other types of gastric carcinoids – should be treated more conservatively.