Pancreatic necrosis develops in 20 % of pancreatitis attacks and is infected in less than 50 % of cases. Biphasic character of the disease afflicts the patient in the first phase by organ failure and later by chronic sepsis resulting from infection. In diagnostics of pancreatitis necrotisans mostly CPR and CT are applied, followed by punctional biopsy with microbiological examination. Antibiotic prophylaxis was left, antibiotic therapy is fundamental with karbapenems. Probiotics are not suitable alternative. Enteral feeding should be provided as soon as possible. Drainage and removal of necroses is doing with miniinvasive approaches and in the late phase of the disease.