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Časopis Gastroenterology for practice – Článok Present overview of aetiology and pathogenesis of chronic pancreatitis

Gastroenterology for practice

Reviewed, postgraduate scientific medical journal.
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné
Téma: 

Present overview of aetiology and pathogenesis of chronic pancreatitis

Petr Dítě, Ivo Novotný, Bohuslav Kianička, Pavel Klvaňa, Hana Nechutová, Martina Bojková, Arnošt Martínek, Arpád Bodai, Miroslav Souček,

Our present knowledge on aetiological factors is documented by a disease classification called TIGARO. Besides “classical” toxonutritive factors, important factors are genetic and autoimmune influence and condition indicating pancreatic duct obstruction. It is known that no more than 10 % of alcoholics will suffer from chronic pancreatitis, out of which is logical a necessity of coexistence of other risk factors for induction of fibrotic gland changes, e.g. combination of alcohol abuse and smoking. An independent factor inducing chronic pancreatitis is the presence of PRSS gene, pro cationic trypsinogen, known as a causal gene of hereditary pancreatitis. Other genes related to origination of chronic pancreatitis, i.e. CFTR mutation and SPINK1 gene do not evoke the disease, but e.g. with alcohol these factors are crucial. In the recent years also a relation between these genes to a tropic form of chronic pancreatitis was proved. Aetiopathogenesis of autoimmune pancreatitis is not exactly known, a characteristic finding is a positivity of immunoglobulin G4 in blood serum and also in pancreatic tissues. But an autoimmune form of pancreatitis is not a homogeneous condition; everything above mentioned is valid for 1st type of the disease, which is the most common. In the second type of the disease IgG4 is not increased, but histologically the findings are virtually equal, with the exception of presence or non-presence of granular endothelial lesions (EGL). The therapy of the autoimmune form was based on administration of steroids and at failure of immunosupressives. Aetiopathogenesis of chronic pancreatitis is apparently multifactorial with differences concerning a clinical course and therapy. Despite of all new knowledge about aetiopathogenesis of the disease it is possible to state that we are only able to treat chronic pancreatitis but not to cure it.

chronic pancreatitis, TIGARO classification, alcohol, genetics, outlet obstruction
Gastroenterol. prax 2013; 12 (2): 68-71

Ročník 2013  Témy časopisu Gastroenterology for practice 2 / 2013

Ladislav Kužela
Petr Dítě, Ivo Novotný, Bohuslav Kianička, Pavel Klvaňa, Hana Nechutová, Martina Bojková, Arnošt Martínek, Arpád Bodai, Miroslav Souček,
Marian Bátovský
Mária Voleková
Anton Vavrečka
Juraj Bober, Jana Kaťuchová
Božena Pekárková, Milan Hlísta
Peter Mlkvý
Ivo Novotný
Peter Hyrdel, Ivan Režňák, Ján Staško, Hubert Poláček, Lukáš Plank, Rudolf Hyrdel
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Nie sú dostupné žiadne voľne dostupné články
CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Rudolf Hyrdel, CSc.

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Marian Bátovský, CSc., mim. prof. SZU
prof. MUDr. Juraj Bober, CSc.
MUDr. Ivan Bunganič
prof. MUDr. Petr Dítě, DrSc.
doc. MUDr. Martin Huorka, CSc.
doc. MUDr. Peter Makovník, CSc.
MUDr. Juraj Májek, PhD.
prof. MUDr. Peter Mlkvý, CSc.
MUDr. Tomáš Šálek
MUDr. Renata Szépeová, PhD.
prof. MUDr. Anton Vavrečka, CSc.
MUDr. Mária Zakuciová

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Ing. Danica Paulenová
e-mail: paulenova@amedi.sk

GRAPHIC LAYOUT AND TYPESETTING
Lucia Vecseiová
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LANGUAGE PROOFREADING
Mgr. Eva Doktorová

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Mgr. Jana Bábelová
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2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
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The editorial board reserves the right to make small stylistic changes in the paper. If it is necessary to shorten the paper, the consent of the author will be required. All articles are reviewed.

Origination of pigment stones is related to:
a. acute haemolysis
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c. hypercalcaemia
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Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné