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Časopis Gastroenterology for practice – Článok The role of genetic mutations in the pathogenesis of chronic pancreatitis

Gastroenterology for practice

Reviewed, postgraduate scientific medical journal.
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné
Téma: 

The role of genetic mutations in the pathogenesis of chronic pancreatitis

Marian Bátovský

Chronic pancreatitis is a persistent inflammation of the pancreas which results in irreversible morphological changes and the impairment of both exocrine and endocrine functions. Genetic studies of hereditary, familial, idiopathic, and tropical forms of chronic pancreatitis have led to the identification of firmly established susceptibility of genes namely PRSS 1, SPINK 1 and CFTR. Relatively newly found disease-causing mutations are mutations of CTRC, CASR and PRSS 2 genes. Two clear loss-of-function mutations in PRSS 1, a missense mutation of SPINK 1 gene and an experimentally demonstrated loss-of-function variant in PRSS 2 protect against chronic pancreatitis. The last findings provided strong support for the hypothesis that chronic pancreatitis is an autodigestive disease in which prematurely activated trypsin within the pancreas was thought to play a pivotal role in triggering of the activation cascade of all pancreatic digestive enzymes.

cationic trypsinogen, anionic trypsinogen, CFTR, SPINK 1, chymotrypsin C, mutation, chronic pancreatitis
Gastroenterol. prax 2013; 12 (2): 72-74

Ročník 2013  Témy časopisu Gastroenterology for practice 2 / 2013

Ladislav Kužela
Petr Dítě, Ivo Novotný, Bohuslav Kianička, Pavel Klvaňa, Hana Nechutová, Martina Bojková, Arnošt Martínek, Arpád Bodai, Miroslav Souček,
Marian Bátovský
Mária Voleková
Anton Vavrečka
Juraj Bober, Jana Kaťuchová
Božena Pekárková, Milan Hlísta
Peter Mlkvý
Ivo Novotný
Peter Hyrdel, Ivan Režňák, Ján Staško, Hubert Poláček, Lukáš Plank, Rudolf Hyrdel
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CHAIRMAN OF THE EDITORIAL BOARD
prof. MUDr. Rudolf Hyrdel, CSc.

MEMBERS OF THE EDITORIAL BOARD
doc. MUDr. Marian Bátovský, CSc., mim. prof. SZU
prof. MUDr. Juraj Bober, CSc.
MUDr. Ivan Bunganič
prof. MUDr. Petr Dítě, DrSc.
doc. MUDr. Martin Huorka, CSc.
doc. MUDr. Peter Makovník, CSc.
MUDr. Juraj Májek, PhD.
prof. MUDr. Peter Mlkvý, CSc.
MUDr. Tomáš Šálek
MUDr. Renata Szépeová, PhD.
prof. MUDr. Anton Vavrečka, CSc.
MUDr. Mária Zakuciová

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Ing. Danica Paulenová
e-mail: paulenova@amedi.sk

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Lucia Vecseiová
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Examples of citations:
1. Vaughan TL, Davis S, Kristal A, et al. Obesity, alcohol and tobacco risk factors for cancers of esophagus and gastric cardia :adenocarcinoma versus squamous cell carcinoma Cancer Epidemiol Biomarkers Prev 1995; 4: 85-92.
2. Gao YT, McLaughlin JT, Gridley T, et al. Risk factors for esophageal cancer in Shanghai, China. Role of diet and nutrients. Int J Cancer 1994; 58: 197-202.
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Send contributions in the e-mail to the address: paulenova@amedi.sk
Period 4x per year
ISSN:1336–1473
The journal is indexed in the Slovak National Bibliography, Bibliographiia Medica Slovaca (BMS) and listed to citation database CiBaMed. All articles are reviewed. The publisher does not bear any responsibility for data and opinions of particular authors of the articles or advertisements. The articles on grey pages are company promotions or non reviewed information, an author is responsible for the content. Any reproduction of the content is allowed only with direct consent of the editorial office.
Predplatné
Gastroenterology for practice
Gastroenterology for practice
Reviewed, postgraduate scientific medical journal.
Period 4x per year
Predplatné