Petr Dítě, Martina Bojková, Tomáš Kupka, Pavel Svoboda, Jarmila Šimová, Nina Dvořáčková, Bohuslav Kianička, Kateřina Kapounková, Arnošt Martínek
Pancreatic carcinoma belongs to the permanent challenges in gastroenterology. Primarily, the pancreatic carcinoma
diagnostics is, from the view of diagnosing curable stages, very complicated. Thank the late diagnostics, the disease is
diagnosed mainly in the advanced stage, and the percentage of effectively treatable pancreatic tumours is about 5 %.
Where not treatable forms of the disease are characterized by not higher than 1 % of survival for 5 years. Identification
of risk factors in pancreatic carcinogenesis is a possible contribution to the identification of early forms of the disease.
An unquestionable risk factor is a chronic inflammation and so also chronic pancreatitis. The risk of carcinoma origination
in sporadic pancreatitis is about 16times higher than in the healthy population, but in people with the hereditary
form, it is 60times higher.
Apparently due to this, the systemic dispensation of people, especially at longer lasting chronic pancreatitis, is an important